The Motorcycle Diaries received widespread critical acclaim upon its release in 2004. The film holds a 93% approval rating on Rotten Tomatoes, with many critics praising its thoughtful and nuanced portrayal of Che Guevara and the journey.

The Motorcycle Diaries is a thought-provoking and visually stunning film that explores themes of identity, social inequality, revolution, and friendship. The film's use of diary entries, cinematography, and music creates a sense of intimacy and immediacy, drawing the audience into the world of the protagonists. As a cultural artifact, The Motorcycle Diaries continues to inspire and challenge audiences, offering a powerful reflection on the human condition and the complexities of social change.

The film's soundtrack, composed by Gustavo Santaolalla, features a mix of traditional South American music, folk, and rock. The music adds to the film's emotional impact, particularly in key scenes, such as the poignant encounter with the beggar in Chile.